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Screening of drugs targeting NMDARs in neuropsychiatric disorders Complicated consequences on NMDAR function including hyperfunction, hypofunction, and no change in function, which are caused by genetic variants of these receptors in neuropsychiatric disorders such as epilepsy, ID, ASD, and schizophrenia, lead to the need for specific drugs targeting these receptors for treating these disorders

Int J Clin Pharmacol Res 18(1):1319 Russell IJ, Kamin M, Bennett RM, Schnitzer TJ, Green JA, Katz WA (2000) Efficacy of tramadol in treatment of pain in fibromyalgia

Randomization was carried out using a minimization approach [Pocock and Simon (1975)] using the following factors: gender, ECOG PS (0 versus 1), response to prior chemotherapy (complete or partial response versus stable disease), history of brain metastases (yes versus no), non-platinum component of induction therapy (docetaxel versus gemcitabine versus paclitaxel), and disease stage (IIIb versus IV)

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