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This role of heavy metals in the causation of oxidative damage suggests that there is a not previously described mechanism involved in metal toxicity, thus prompting scientists to conduct investigations whether heavy metals are involved in the oxidative deterioration of biological macromolecules

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Lewis, The effect of ascorbate and -tocopherol supplementation in vitro on DNA integrity and hydrogen peroxide-induced DNA damage in human spermatozoa, Mutagenesis, 1999, doi: 10.1093/mutage/14.5.505