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Obesity alters oestrogen metabolism and contributes to pulmonary arterial hypertension

Furthermore, ROS can be released in response to a variety of stimuli, such as TNF- and lipopolysaccharide [3646, 169] and they serve as intracellular signals for the activation of redox-sensitive transcription factors [2, 3, 1618, 26, 27, 3646, 164170]