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A primary challenge lies in SFNs suboptimal pharmacokinetic profile, characterized by rapid metabolism, limited oral bioavailability, and chemical instability

[DOI] [PubMed] [Google Scholar] 155.Hassan S.S., Razzaque A., Ahmad Z., Pazdernik V., Amin S.N

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Elife 5 , 116 (2016)

Perluigi M, di Domenico F, Butterfield DA (2015) mTOR signaling in aging and neurodegeneration: at the crossroad between metabolism dysfunction and impairment of autophagy