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The viability (%) of the silymarin NCs was calculated utilizing Eq

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The remaining 24 arthritic and 20 control rats were randomly assigned to treatment or placebo groups

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4 examined the effects of PI-based intermittent therapy or treatment in combination with histone deacetylase (HDAC) inhibitors on drug-tolerant MM cells, and demonstrated that the combination of HDAC inhibitors and high-dosage intermittent therapies, as opposed to sustained PI monotherapy, can be more effective in treating MM by preventing the emergence of PI-tolerant cells (Fig