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Start with once-daily application and observe for any reaction before increasing to twice daily

doi: 10.1016/j.molcel.2020.11.024 64 LiuJKangRTangD

The main discrepancies that we observed across the literature were about which is the first metabolic abnormality induced by arsenic

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18 A 2019 Cochrane review of eight RCTs of NAC alongside standard treatment versus standard treatment alone or standard treatment with placebo 41 found that when pooling data from all studies, the improvement in eradication rates failed to reach statistical significance, but when only data from those five RCTs that used current eradication regimens (triple therapy in four RCTs