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Particularly in tumor cells with active glycolysis, accumulated lactate stabilizes and increases the activity of proglycolytic transcription factors such as HIF-1 and c-Myc, as well as the expression of their downstream target genes, via lactylation, thereby forming a self-reinforcing positive feedback loop that further entrenches the glycolytic phenotype of tumors [78, 79]

Curran CS, Kopp JB (2023) The complexity of nicotinamide adenine dinucleotide (NAD), hypoxic, and aryl hydrocarbon receptor cell signaling in chronic kidney disease

Despite all of the above, one caveat: Since sauerkraut is fermented with salt, its high in sodium

It is important to note that a decrease in the degradation rate of autophagy substrates, caused by reduced lysosomal function due to endoplasmic reticulum stress, can weaken the overall autophagy process

Abnormal behavior in a chromosome-engineered mouse model for human 15q11-13 duplication seen in autism