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In the area of molecular biology and pharmacology, its active thiol (-SH) group on the cysteine residue can donate electrons to neutralize reactive oxygen species (ROS) and free radicals, so as to recover the cellular redox homeostasis, and prevent biomolecules (proteins, lipids, and nucleic acids) from being oxidized

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Monoamine oxidase (MAO), another copper-dependent enzyme, is involved in the metabolism of serotonin and DA

However, the GSSG form can be converted back into GSH by glutathione reductase and NADPH

And TGF-1, released into the TME, activates the SMAD3 pathway in memory CD8 + T cells, ultimately impairing their anti-tumor activity (338)