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We initially explore the relationship between metabolism, polarization, and disease, before delving into recent NM innovations that visualize macrophage activity to elucidate disease onset and fine-tune its fate through metabolic remodeling for macrophage-centered immunotherapy

360 Mitochondrial pyruvate carrier (MPC) deletion promotes metabolic flexibility by generating acetyl-CoA through glutamine and fatty acid oxidation, enhancing pre-memory gene histone acetylation and chromatin accessibility, thereby driving CD8 + T-cell differentiation toward a memory phenotype

608 YimerG.AmogneW.HabtewoldA.MakonnenE.UedaN.SudaA.et al (2012)

Immuno-profiling and cellular spatial analysis using five immune oncology multiplex immunofluorescence panels for paraffin tumor tissue

Preclinical studies with PLGA-based nanoparticles carrying tenofovir or efavirenz have demonstrated detectable plasma levels in rodent with release duration influenced by polymer composition (e.g., lactide: glycolide ratio) and particle size [69]