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It is also why rushing to a higher dose in the first week or two before steady state is reached often leads to unnecessary side effects

Clemmons DR, Moses AC, Sommer A et al (2005) Rh/IGF-I/rhIGFBP-3 administration to patients with type 2 diabetes mellitus reduces insulin requirements while also lowering fasting glucose

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Administration Precautions: Before each administration, the vial should be inspected visually for any particulate matter or discoloration