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Retatrutides glucagon receptor activity may increase energy expenditure and influence fat metabolism, although it can also affect heart rate and gastrointestinal tolerance in some individuals

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This may probably be due to a generally higher metabolic activity in older fish with higher body mass compared to younger ones [84]

Furthermore, the combined deficits in Se and Zn may worsen thyroid dysfunction by restricting the synthesis of hormones and the enzymatic conversion of T4 to T3

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