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As chronic PE induces tissue changes that go beyond skeletal muscle tissue (e.g., increase in mitochondria in adipose tissue), it is plausible that changes such as improvement in mitochondrial metabolism (improves their structure and function) in the epidermis also could occur in response to physical training practice (see Figure 6)

Fasting has been shown to reduce inflammatory markers in the body, which can help preserve glutathione levels

doi: 10.1016/j.cgh.2022.09.008 123 HeRLiPWangJCuiBZhangFZhaoF