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The plantar fascia has relatively poor blood supply, which is why plantar fasciitis becomes such a stubborn, chronic condition

Discovery of Hydroxytyrosol as thioredoxin reductase 1 inhibitor to induce apoptosis and G1/S cell cycle arrest in human colorectal cancer cells via ROS generation

However, the skin barrier results in poor transdermal permeability of drugs, making it difficult for them to penetrate deep into tissues to exert therapeutic effects