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Blocking this antioxidant axis with SLC7A11 and GPX4 inhibitors (ferroptosis inducers) such as the small-molecule Erastin and RSL3, respectively, leads to uncontrolled accumulation of lipid peroxides at the plasma membrane and other endomembranes within the cell, which promotes membrane permeabilization, damages membrane integrity and ultimately induces ferroptosis [34, 38]

These adaptations are regulated by hypoxia-inducible factor-1 (HIF-1), which controls various biological pathways

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The implantation of artificial lenses, sterilized with ethylene oxide, in 103 eyes was compared with the implantation of lenses, sterilized with sodium hydroxide (200 control eyes), in a retrospective study