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10.1016/j.biochi.2024.06.006 136 ShannonE.Abu-GhannamN

Human and animal rights and informed consent This article does not contain any studies with human or animal subjects performed by any of the authors

The improvements includes oxidative stress, glutathione deficiency and multiple aging hallmarks affecting mitochondrial dysfunction, mitophagy, inflammation, insulin resistance, endothelial dysfunction, genomic damage, stem cell fatigue and cellular senescence

For instance, a multi-omics study integrating epigenomics, whole-genome sequencing, and metabolomics uncovered previously unrecognized pathways implicated in T2DM, underscoring the value of systems-level strategies in unraveling complex disease mechanisms (154)

H&E staining was performed to assess viable osteocytes