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doi: 10.7150/ijbs.12118 191 ZhangCSunCZhaoYYeBYuG

Mutations in mitochondrial DNA (mtDNA), commonly detected across cancers such as renal oncocytoma, gastric adenocarcinoma, renal cell carcinoma, bladder cancer, ovarian cancer, thyroid cancer, and pancreatic cancer, 208,209,210,211,212,213,214,215 can disrupt OXPHOS, enhance ROS production, and promote tumorigenesis

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Of all COVID-19 cases, approximately 81% have mild disease, 14% severe disease, and 5% develop critical illness [82]