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There are approximately 200[21] mutations and 400 biochemical variants of G6PD

For example, paramagnetic metals can participate in ROS production through Fenton or Haber-Weiss reactions, which, at elevated levels, may cause oxidative damage to proteins, nucleic acids, and lipids, leading to cell death (Shabanpour et al., 2024)

doi: 10.3390/toxins8110326 246 SubramaniamSFletcherC

132 In addition, interim analysis from a small higher dose study using twice-weekly 300 mg atesidorsen for 13 weeks demonstrated results consistent with the Phase II trial outcomes (Antisense Therapeutic Ltd.)

Finally, in the probe phase of the Barnes maze test, Sham control mice took on average approximately 6s to find the escape pod zone