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Description

mTOR at the nexus of nutrition, growth, ageing and disease

(PubMed) National Institutes of Health NOEI

As expected, PS-CHO@ATRA-SS-ATRA exhibited highest down-regulation of Sox2 , Nanog and Oct4 genes in all formulations, further confirming that the ALDH-activated nano-prodrug could effectively eliminate the CSC and reduce the CSC-enriched microenvironment