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This is likely because eosinophils also must be activated to degranulate and/or release their inflammatory mediators

10.1016/S0006-8993(98)00531-9 202 YuY.ZhangL.YinX.SunH.UhlG

Many conventional antimicrobials lose activity upon linker attachment, while emerging payload classes, including nucleotide analogues and metal-based complexes, frequently exhibit altered pharmacokinetics or aggregation when conjugated (Yamazaki et al., 2021)