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Mitochondrial ROS production and oxidative mtDNA damage is increased during reoxygenation in the GPX1 knockout mice, in addition to structural abnormalities in cardiac mitochondria and myocytes, suggesting GPX1 may play an important role in protecting cardiac mitochondria from reoxygenation damage in vivo

For example, GPx1 has been reported to prevent oxidative DNA mutations, which in turn may prevent the development of tumors [42], and research shows that overexpression of GPx1 can reduce tumor growth, indicating its inhibitory effect in tumorigenesis [43]

Liraglutide attenuates glucolipotoxicity-induced RSC96 schwann cells inflammation and dysfunction

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McFadden and colleagues also reported improvements in quality of life and pulmonary function tests (PFTs) and a reduction in systemic and topical corticosteroid requirements[83]