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Semin Oncol 1983

NADPH has multiple functions such as maintaining the reducing state of GSH, protecting membrane proteins, hemoglobin, and preventing the oxidation of enzyme protein thiol groups, and the levels of NADPH in the cytoplasm and cytosol have regulatory effects on ferroptosis (Ding et al., 2020

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T cell receptor engagement induces Ca 2+ release, which in turn augments mitochondrial functional roles including the tricarboxylic acid (TCA) cycle and ROS generation [74]