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Specifically, hypomethylation of UDP-glucose ceramide glucosyltransferase like 1 ( B3GNTL1 ) and homeobox D8 ( HOXD8 ), combined with hypermethylation of the homeobox B4 ( HOXB4 ), HOXA7 , integrin subunit alpha 4 ( ITGA4 ), zinc finger protein 808 ( ZNF808 ), and prostaglandin E receptor 4 ( PTGER4 ) genes, demonstrated significant accuracy for the detection of early-stage LUAD patients [121]

Data was normalized by median coverage, filtered by a standard deviation of 2, and assessed for outliers

References Hotez PJ, Fenwick A, Savioli L, Molyneux DH: Rescuing the bottom billion through control of neglected tropical diseases

Regen Biomater

Although AtDHAR1 and AtDHAR3 are either weakly or not expressed in pollen, this may be compensated by AtDHAR2 which has its highest expression in this organ (Figure 4)