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Spread or worsen over time

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This process was primarily driven by the abnormal proliferation of Fusobacteriota and Bacteroidota: Bacteroidota could efficiently degrade host mucins and polysaccharides, providing essential carbon and energy sources for the community, while Fusobacteriota might exploit their secreted virulence factors, such as leukotoxins and extracellular proteases, to disrupt the mucosal structure 117

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Dexmedetomidine protects against lipopolysaccharide-induced acute kidney injury by enhancing autophagy through inhibition of the PI3K/AKT/mTOR pathway