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A 2015 study published in the Annals of Clinical and Laboratory Science found that intra-articular (injected into the joint) AOD-9604 enhanced cartilage regeneration in a rabbit model of knee osteoarthritis

Hence the estimations of LOCF and MMRM are based on all data until last observation on treatment and extrapolating the remaining data until the planned end of treatment at week 56 (Table 2)