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To evaluate Dihexas ability to cross the BBB and accumulate in brain regions, rats were fitted with carotid cannulas and infused with a mixture of [H]Dihexa (10 Ci) and [C]inulin (2 Ci), a vascular space marker, in 100 l of isotonic saline

Stable knockdown was confirmed by qRT-PCR and Western blot, which showed substantial reductions in SLC25A39 mRNA and protein levels with minimal effect on SLC25A40 expression (Fig

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