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This translates to a relative reduction in liver fat by 37%, indicating a possible benefit in lowering liver fat accumulation

Drug resistance remains one of the leading bottlenecks contributing to unsatisfactory therapeutic outcomes and eventual treatment failure during clinical cancer chemotherapy, and abundant preclinical evidence has confirmed that abnormally elevated NNMT expression is closely correlated with acquired drug resistance across various solid and hematologic malignancies

Tirzepatide, by contrast, adds the GIP pathway within the same molecule: it co-activates the GIP receptor, a mechanism entirely absent from CagriSema

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This "step therapy" approach, common in pharmaceutical benefit management, could make orforglipron the default first-line GLP-1 therapy for many patients, with injectable options reserved for orforglipron non-responders or patients with specific clinical needs for higher efficacy