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Int J Mol Sci 24(10):8465

Plant Physiol 187(4):19291939

doi: 10.1172/jci.insight.125937 69 LewisH

26 Patients with a congenital deficiency of the enzyme MTHFR, which is needed for the formation of 5-methylTHF, have reduced levels of both methionine and SAMe in the cerebrospinal fluid and show demyelination in the brain and degeneration of the spinal cord