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Peer review Peer review information Nature Communications thanks Lei Jiang and the other anonymous reviewer(s) for their contribution to the peer review of this work

Why: Isotretinoin is derived from vitamin A and combining the two increases the risk of hypervitaminosis A , which can cause: Headaches / pseudotumour cerebri Liver toxicity Nausea Bone pain Skin peeling Mood changes Avoid: Vitamin A capsules Multivitamins containing high-dose retinol Cod liver oil (contains vitamin A) Most multivitamins have Vitamin A with very low levels ( 5,000 mcg

Jiang YJ, Li X, Xue Z, Yin K, Xu J, Su

Paraffin-embedded sections (4 m) were cut and mounted on a coated glass slide

We observed that GLP-1MK-801 has similar receptor signalling properties at the GLP-1 receptor compared to the parent GLP-1 analogue as well as to the pharmacokinetically optimized GLP-1 receptor agonists semaglutide and liraglutide (Extended Data Fig