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To understand this complex relationship, lets take a look at oxidative stress

10.1016/j.chom.2016.07.019 Cell Host Microbe 41 HoekK

Shimmura C, Suzuki K, Iwata Y, Tsuchiya KJ, Ohno K, Matsuzaki H, Iwata K, Kameno Y, Takahashi T, Wakuda T, Nakamura K, Hashimoto K, Mori N (2013) Enzymes in the glutamate-glutamine cycle in the anterior cingulate cortex in postmortem brain of subjects with autism

ZhangMZhangXTianTZhangQWenYZhuJet alAnti-inflammatory activity of curcumin-loaded tetrahedral framework nucleic acids on acute gouty arthritis

Researchers have hypothesized that Ashwagandha may reduce cortisol levels, hence reducing the HPA axis activity