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Ipamorelin is a synthetic pentapeptide (Aib-His-D-2-Nal-D-Phe-Lys-NH2) classified as a selective ghrelin/growth hormone secretagogue receptor (GHS-R) agonist

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However, as the injury becomes chronic, persistent exposure to immunomodulatory signalsincluding IL-10, TGF-, oxidized phosphatidylethanolamines (oxPEs), and lipid aldehydes like 4-HNEprogressively skews macrophages toward a profibrotic M2-like phenotype (106)

We observed a consecutive upregulation of molecules associated with inflammation in MI animals throughout the 300-min follow-up period, with strong upregulation of osteopontin, periostin and c-reactive protein (Fig

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