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In addition, sample distribution and well positions were balanced across the two plates to further minimize analytical bias

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Using them together means you're not relying on one pathway when you could be addressing two simultaneously

When comparisons have been made, they often suggested that MAFLD may more selectively identify patient populations at risk of severe liver-related and extra-hepatic outcomes [11]

We recently determined the structure of the coiled-coil complex formed between MBD2 and the p66 protein and showed that disrupting this interaction restores expression of methylated genes.1 Since knockout of MBD2 in mice leads to only mild phenotypic consequences, inhibition of MBD2 represents a potential biological target to restore expression of tumor suppressor genes silenced by DNA methylation