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In the MyD88 pathway, a series of downstream molecules are sequentially activated following recruitment of MyD88, including but not limited to interleukin-1 receptor-associated kinases (IRAKs), tumor necrosis factor (TNF) receptor-associated factor 6 (TRAF6), interferon (IFN) regulatory factor 5 (IRF5), receptor-interacting protein kinase 1 (RIP1), nuclear factor B (NF-B) inhibitor (IB) kinase (IKK) complex, finally leading to the activation of mitogen-activated protein kinases (MAPKs) (ERK, JNK, p38) and NF-B, which induces a wide range of pro-inflammatory cytokines (227, 228)

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