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Buhaescu, S

Inactivation of rabbit muscle glyceraldehyde-3-phosphate dehydrogenase by koningic acid

For example, benzene oxide, a reactive species and the first oxidation product of benzene (Figure 1), has been recently shown to be somewhat stable in blood (half-life of 8 min).97 Moreover, benzene oxide adducts with proteins have been measured in rat and mouse bone marrow following administration of benzene.68 The relative importance of benzene oxide to other metabolites is not known at this time

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Overall, the activation of RAAS in DKD results in renal tubular injury through inflammation, hypoxia, fibrosis, and altered sodium and water handling