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4 Other trials on NAD+ for addiction typically had patients use 500-1000mg of NAD+ in 300mL of normal saline typically with a loading period of daily dosing for four days, followed by a taper period of twice weekly dosing for a month, and finally reducing to just twice monthly dosing until resolution of addiction

Glucose Metabolism Preservation: Metabolic assessments included fasting glucose, fasting insulin, oral glucose tolerance tests in some studies, and calculation of insulin sensitivity indices