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Data processing and downstream analysis for ABPP in SK-MEL-103 senescence Raw.d files were searched in Spectronaut 19 in directDIA mode against the canonical UniProt human FASTA (downloaded 20240122, 20,596 entries) according to default modifications and settings with the following amendments: no cross-run normalization or imputation was applied, and protein inference was set to all matching proteins

We assessed the diverse functional association of protein domains by analysing core functional clans, and determined similar patterns of dominance for carbohydrate, amino acid and lipid processing-associated domains (Supplementary Fig

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The foundation of AR-directed therapy lies in either the withdrawal of the natural ligand, the so-called androgens, or the direct deactivation of the AR by so-called antiandrogens (e.g., apalutamide, enzalutamide, or darolutamide) [181,182]