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Specifically, the pathogenesis of PH is driven by factors such as mutations in the type II bone morphogenetic protein receptor (BMPR2), chronic inflammation, fibrosis, immune activation, and mitochondrial metabolic dysfunction (Thenappan et al., 2018)

However, it has been previously demonstrated that the administration of vitamin B-6 (100 mg/kg) considerably ameliorated the chromium-induced oxidative stress in rats [29]

This effect is usually mild and resolves after cessation of use or dose reduction

Glycogen synthase kinase-3 (GSK3) in psychiatric diseases and therapeutic interventions