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The in vitro experiments have confirmed that vitamin D could inhibit the growth of Mtb and secretion of pro-inflammatory cytokines in peripheral blood monocytes (Martineau et al., 2007), stimulate the receptor-induced expression of antimicrobial peptides, and up-regulate LL37 gene to induce the autophagy-related proteins Atg5 and Beclin-1 to mediate the killing effect (Periyasamy et al., 2020)

Moreover, changes in the content of bioactive lipids or increased oxidative modifications to HDLs lipids and protein cargo likely confer dysfunction

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The peptides work by interacting with the IGF-1 receptor to support processes such as cell growth, differentiation, and regeneration, which are crucial for muscle development and metabolic efficiency

It often comes from tight muscles or hormone changes in the body