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The osteoblastic differentiation of VSMCs is currently considered responsible for the formation of vascular calcification

These intermediates are metabolic precursors of amino acids, nucleotides, fatty acids, hemes, and porphyrins, which are essential components for synthesizing cell membranes, DNA, proteins, and other macromolecules ( It is appropriate to mention that similar to glycolysis, the TCA cycle can generate two ATPs from substrate-level phosphorylation, which occurs when the succinic CoA synthetase enzyme catalyzes the reversible reaction of succinyl CoA to succinate (Martnez-Reyes and Chandel, 2020)

The HHV8 human herpesvirus is the cause of Kaposi's sarcoma (KS)

107,108 Beyond direct effects on insulin signaling, SIRT1 indirectly modulates insulin sensitivity by regulating autophagy via the mTOR pathway

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