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iodothyronine (T4) deiodinase Conversion to rT3 reduces the reservoir of T4 that can be converted to T3

Lavrynenko O, Titz B, Dijon S, Santos DD, Nury C, Schneider T, et al

Meza-Junco J, Chu QS, Christensen O, Rajagopalan P, Das S, Stefanyschyn R, et al

A phase 3 double-blind, double-dummy, randomised controlled trial (RCT) comparing IPX203 with immediate-release (IR) LD/CD showed a statistically significantly greater increase in daily ON-time of + 0.53 h, and this difference was achieved with a mean of 3 daily doses vs 5 in the IR LD/CD arm [22]