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Given the recognised mechanistic similarities between lactylation and acetylation in regulating chromatin accessibility and gene expression patterns [25, 26], it is biologically plausible that lactylation contributes to mesangial cell activation through analogous epigenetic mechanisms

Hepcidin, a liver-derived peptide hormone, also exerts a crucial negative feedback role in cerebral iron regulation

L-carnitine may have additional benefits for the dialysis patient: a meta-analysis of 49 clinical trials involving 1734 kidney dialysis patients found a significant decrease in C-reactive protein (a marker of inflammation) and low-density lipoprotein in patients taking carnitine

Approximately 50% of patients develop hypocalcaemia due to chelation of calcium by oxalic acid

Lewis DJ