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In addition to GSTM5, various subunits of glutathione S-transferase and gamma-glutamyltransferase were consistently downregulated in Fabry kidney organoids

Interestingly, Chac1 was downregulated across the entire disease spectrum, beginning in early MASLD and remaining suppressed through progression to MASH with advanced fibrosis (Figure 6D)

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As the hair shaft primarily comprises keratin, enriched in cysteine, we postulate that these trichoscopic signs might be manifestations of localized reduction or metabolic disturbances of cysteine in keratin