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The discovery of place cells is credited to John O'Keefe in 1971(1), who won the Nobel Prize for his discovery jointly with colleagues May-Britt and Edvard Moser in 2014 (2)

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Several growth factors have been tested in vitro and most have been shown to successfully decrease cell apoptosis and/or to enhance chondrogenic matrix production, and/or to direct MSC differentiation towards a NP-like phenotype

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