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also found an upregulation of the autophagy marker protein LC3 downstream of CHAC1, suggesting an autophagy-mediated induction of ferroptosis (Ying et al., 2025)

Archived from the original on 20 March 2013

While iron is essential for normal cellular function, its excess catalyzes the Fenton reaction, generating reactive oxygen species (ROS) that damage lipids, proteins, and DNA

And let's not forget the brain

Diabetes Metab Syndr 3(2):120127 Pazicni S, Lukat-Rodgers GS, Oliveriusov J, Rees KA, Parks RB, Clark RW et al (2004) The redox behavior of the heme in cystathionine -synthase is sensitive to pH