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PMC 4336627

Mounting evidence implicates the GBA in the pathogenesis of multiple chronic diseases, including inflammatory bowel disease, coeliac disease, allergies, asthma, metabolic syndrome, cardiovascular disease, and obesity [51], and the pathology of numerous neurological and psychiatric disorders

Such different effects of polyphenols enable them to exert biological activity via mechanisms that lead to free radical scavenging, mitochondrial protection, transcription factor regulation, membrane receptor modulation and inhibition of ROS and cellular proliferation [97,98]

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These antioxidant systems include the GPX4 system, free radical scavenging antioxidant systems (such as the FSP1-COQH2 system, DHODH-CoQH2 system, and GCH1-BH4 system), and membrane repair systems ( Figure 1 )