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Jain, A., et al.,p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription

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62 Two double-blind RCTs investigated the effectiveness of B12 in adults who had been suffering from low back pain for more than 6 months, and both found significantly better pain reduction in the B12 compared with the placebo group