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Transition strategies Hard stop (complete break): Finish peptide A completely Wait 2-4 weeks Start peptide B fresh When to use : Switching to very different peptide Need assessment period Want clean slate Example : Finish semaglutide (weight loss) 3 week break Start Ipamorelin/CJC (muscle building) Overlap (run both simultaneously): Continue peptide A Start peptide B Both run together briefly Stop peptide A when peptide B established When to use : Complementary peptides Don't want any gap in benefits Stacking makes sense Example : Running BPC-157 Add TB-500 for enhanced healing Continue both 8 weeks Taper (gradual reduction): Slowly reduce peptide A dose Simultaneously ramp peptide B Smooth handoff When to use : Avoiding sudden changes Sensitive to fluctuations Weight loss peptides especially Example : Semaglutide 2.4mg weekly 2mg 1.5mg 1mg while starting maintenance approach Maintenance bridge : Reduce peptide A to maintenance dose Start peptide B at full dose Maintain low-dose peptide A indefinitely When to use : Want sustained benefits from peptide A Adding new goal with peptide B Can afford both Example : BPC-157 250mcg daily (maintenance) + Ipamorelin/CJC full protocol (performance) Common transition scenarios Injury to performance : 12 weeks BPC-157 + TB-500 (healing) Hard stop 2 weeks 16 weeks Ipamorelin + CJC-1295 (building) Fat loss to muscle gain : 24 weeks semaglutide (cut to goal weight) Taper semaglutide over 4 weeks Start Ipamorelin + CJC-1295 during taper 16 weeks muscle building Performance to maintenance : 16 weeks full GH peptide stack Reduce to 2-3x weekly dosing Add BPC-157 for joint protection Ongoing maintenance Use our peptide stack calculator to plan transitions

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This process leads to increased expression of COX-2 and iNOS, as well as the release of various cytokines [117, 118]

[Abstract]2026 Jul;137(1):154-167