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The spleen, which is located in the upper abdomen, makes antibodies and removes old and damaged red blood cells (4)

Furthermore, synthetic -carotene (10100 M) may reduce the phosphorylation of JAK2 and STAT3, suggesting that its anti-inflammatory effect could be mediated through the inhibition of the JAK2/STAT3 signaling pathway, and it also reduces the phosphorylation of NF-B, JAK2, STAT3, JNK, and p38 in murine macrophage cell line RAW264.7 and murine peritoneal macrophages obtained from BALB/c mice [30], which are activated by LPS [31,32]

Interestingly, TRIM37-deficient cells become autophagy addicted, and so inhibition of autophagy flux in these cells leads to pronounced cell death (Wang W

Maestri et al., 2010)

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