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Thiamine ameliorates diabetes-induced inhibition of pyruvate dehydrogenase (PDH) in rat heart mitochondria: Investigating the discrepancy between PDH activity and PDH E1alpha phosphorylation in cardiac fibroblasts exposed to high glucose

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Schiller et al., 1993)

This approach frequently leads to chronic instability, recurrent injuries, and long-term dysfunction that could have been prevented with appropriate intervention during the initial healing window