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The microsomal system, on the other hand (active CYP2E1), stimulates the generation of ROS, notably superoxide and hydroxyl radicals, resulting in oxidative stress and cell death

FIGURE 4 Finally, to investigate the difference in the responses to the AA stimulation between HepG2 single cells and 3D spheroids, we use 1.5 m AA to stimulate both of them and then use the plasmonic gel film to perform time-lapse detection of H 2 O 2 in the complete culture media

The content of Fe 2+ is strictly regulated, and when its level is out of balance, excess ferrous will provide electron-promoting lipid peroxidation via Fenton reaction, resulting in an increased production of ROS and inducing ferroptosis (Kajarabille and Latunde-Dada 2019

Olaparibs capacity to suppress MDSCs and enhance T-cell function, particularly in combination with anti-PD-1 therapy, underscores its potential role in immunotherapy for MSS tumors