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Molecular basis of the multifaceted functions of human leucyl-tRNA synthetase in protein synthesis and beyond

PMC7210561 Scientifique-FNRS, Belgium

6G suppressed the growth of lung cancer cells by inhibiting USP14 expression, leading to a significant increase in the number of autophagosomes, ROS levels, and iron concentration, as well as regulating downstream autophagy-dependent ferroptosis-related proteins including nuclear receptor coactivator 4 (NCOA4), FTH1, TfR1, GPX4, and activating transcription factor 4 (ATF4) (120)